![]() Considering that insulin mitigates beta-amyloid deposition and phosphorylation of tau, pharmacological strategies restoring brain insulin signaling, such as intranasal delivery of insulin, could have significant therapeutic potential in AD treatment.Īlzheimer's disease (AD) is the most common cause of dementia. In detail, we will focus on the role of insulin signaling in the deposition of neuritic plaques and intracellular NFTs. In this review we will discuss the role played by aberrant brain insulin signaling in AD. However, the precise mechanisms involved in the development of AD in patients with diabetes are not yet fully understood. ![]() Indeed insulin resistance, increased inflammation and impaired metabolism are key pathological features of both AD and diabetes. Recent studies suggest that AD may be linked to brain insulin resistance and patients with diabetes have an increased risk of developing AD compared to healthy individuals. Insulin signaling is involved in numerous brain functions including cognition and memory that are impaired in AD. For long time, it was considered that insulin signaling has only peripheral actions but now it is widely accepted that insulin has neuromodulatory actions in the brain. AD etiology appears to be linked to a multitude of mechanisms that have not been yet completely elucidated. AD is a multifaceted pathology characterized by accumulation of extracellular neuritic plaques, intracellular neurofibrillary tangles (NFTs) and neuronal loss mainly in the cortex and hippocampus. 4Department of Clinical and Experimental Medicine, University of Foggia, Foggia, ItalyĪlzheimer's disease (AD) is the most common form of dementia affecting elderly people.3Department of Medical and Surgical Sciences, University of Foggia, Foggia, Italy.2Department of Biochemical Sciences, Sapienza University of Rome, Rome, Italy.Erspamer,” Sapienza University of Rome, Rome, Italy 1Department of Physiology and Pharmacology “V.Shot by UWRFW ABIGAIL STOW MISSED, save Mackenzie Torpy.įaceoff MADI NOLAN vs Maddy Fiedler won by UST-WOM.įaceoff HAILEY HERDINE vs Shae McLean won by UWRFW.įaceoff SAM YOUNG vs Maddy Fiedler won by UST-WOM.Gaurav Bedse 1,2, Fabio Di Domenico 2, Gaetano Serviddio 3 and Tommaso Cassano 4 * Shot by UWRFW KORA TORKELSON MISSED, save Mackenzie Torpy. Shot by UST-WOM Shae McLean MISSED, save SAMI MILLER.įaceoff SAM YOUNG vs Maddy Fiedler won by UWRFW. Shot by UST-WOM Rachel Werdin MISSED, save SAMI MILLER.įaceoff HAILEY HERDINE vs Shae McLean won by UST-WOM. Shot by UST-WOM Estee Frantz MISSED, save SAMI MILLER. ![]() ![]() GOAL by UST-WOM Allison Parnell, Assist by Anna Williams, On ice for UST-WOM: Allison Parnell Heidi Hannula Shae McLean Anna Solheim Anna Williams, On ice for UWRFW: HALEY NIELSEN BELLA WAGNER SAM YOUNG ASHLEY EFFERTZ KATHRYN LARSON, goal number 4 for season.įaceoff BELLA WAGNER vs Chloe McEnelly won by UWRFW.įaceoff SAM YOUNG vs Chloe McEnelly won by UST-WOM. Shot by UWRFW HAILEY HERDINE MISSED, save Mackenzie Torpy.įaceoff SAM YOUNG vs Shae McLean won by UST-WOM. Period #2 Plays Period #2 Plays UWRFW - Play Descriptionįaceoff HAILEY HERDINE vs Maddy Fiedler won by UWRFW. Shot by UWRFW MADI NOLAN MISSED, save Mackenzie Torpy. HAILEY HERDINE (UWRFW) penalty complete. Shot by UST-WOM Anna Williams MISSED, save SAMI MILLER. Penalty on HAILEY HERDINE UWRFW 2 minutes for HOOKING, (power play opp). Chloe McEnelly (UST-WOM) penalty complete.įaceoff HAILEY HERDINE vs Chloe McEnelly won by UWRFW. Shot by UWRFW BELLA WAGNER MISSED, save Mackenzie Torpy. Penalty on Chloe McEnelly UST-WOM 2 minutes for HIGH STICKING.įaceoff REILLY SPRINGMAN vs Estee Frantz won by UWRFW. Penalty on MADI NOLAN UWRFW 2 minutes for INTERFERENCE, (power play opp).įaceoff HAILEY HERDINE vs Estee Frantz won by UWRFW.įaceoff BELLA WAGNER vs Shae McLean won by UWRFW. Shot by UWRFW ALYSON NIEBUR MISSED, save Mackenzie Torpy.įaceoff BELLA WAGNER vs Chloe McEnelly won by UST-WOM. Shot by UWRFW CALLIE HOFF MISSED, save Mackenzie Torpy. Shot by UST-WOM Chloe McEnelly MISSED, save SAMI MILLER.įaceoff SAM YOUNG vs Chloe McEnelly won by UWRFW. Shot by UST-WOM Maddy Fiedler MISSED, save SAMI MILLER. GOAL by UWRFW REILLY SPRINGMAN (FIRST GOAL), Assist by ANDREA OLSON, On ice for UWRFW: KIANA GILBRAITH HAILEY HERDINE IZZY BROSSEAU REILLY SPRINGMAN ABIGAIL STOW, On ice for UST-WOM: Chloe McEnelly Estee Frantz Sarah Moy Mikayla Kero Heidi Hannula, goal number 5 for season.įaceoff HAILEY HERDINE vs Maddy Fiedler won by UST-WOM. Shot by UST-WOM Demi Cooper MISSED, save SAMI MILLER.įaceoff MADI NOLAN vs Shae McLean won by UWRFW.įaceoff MADI NOLAN vs Chloe McEnelly won by UST-WOM. Mackenzie Torpy at goalie for UST-WOM.įaceoff BELLA WAGNER vs Maddy Fiedler won by UWRFW.įaceoff BELLA WAGNER vs Shae McLean won by UST-WOM. Period #1 Plays Period #1 Plays UWRFW - Play Description
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